Lacidipine (GX-1048, GR-43659X, SN-305, Lacipil, Motens)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$430	Check With Us
1g	$700	Check With Us
5g	$2000	Check With Us

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Cat #: V1199 CAS #: 103890-78-4 Purity ≥ 98%

Description: Lacidipine (GX-1048, GR-43659X, SN-305; GX1048, GR43659X, SN305; Caldine, Lacimen, Lacipil, Midotens, Motens) is a potent and 3rd-generation L-type CCB (calcium channel blocker) that has been approved in 1990s for treating high blood pressure.

References: Cristofori P, et al. The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse. J Hypertens. 2000 Oct;18(10):1429-36.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	455.54
Molecular Formula	C26H33NO6
CAS No.	103890-78-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 91 mg/mL (199.7 mM)r
	Water: <1 mg/mLr
	Ethanol: 22 mg/mL (48.3 mM)
Solubility In Vivo	NA
Synonyms	GX-1048, GR-43659X, SN-305; GX 1048, GR 43659X, SN 305; GX1048, GR43659X, SN305; Lacipil, Motens

Protocol	In Vivo	Lacidipine (0.3, 1.0, 3.0 mg/kg; p.o.; single daily for 10 weeks) shows anti-atherogenic effects in the apoE-deficient mouse, and reduces plasma endothelin concentrations
	Animal model	Female C57BL/6 mice (Homozygous; apoE-deficient; atherosclerosis model)
	Dosages	0.3, 1.0, 3.0 mg/kg
	Administration	Oral gavage; single daily for 10 weeks.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1952 mL	10.9760 mL	21.9520 mL	43.9039 mL
5mM	0.4390 mL	2.1952 mL	4.3904 mL	8.7808 mL
10mM	0.2195 mL	1.0976 mL	2.1952 mL	4.3904 mL
20mM	0.1098 mL	0.5488 mL	1.0976 mL	2.1952 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.