Ranolazine 2HCl (RS-43285; CVT-303)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
2g	$240	Check With Us
5g	$500	Check With Us
10g	$750	Check With Us

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Cat #: V0368 CAS #: 95635-56-6 Purity ≥ 98%

Description: Ranolazine 2HCl (known also as Ranolazine diHydrochloride), the diHCl salt of ranolzaine (RS43285; CVT303), is a an anti-angina drug which acts as a potent calcium uptake inhibitor via the sodium/calcium channel, it is used to treat chronic angina.

References: Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	500.46
Molecular Formula	C24H33N3O4.2HCl
CAS No.	95635-56-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (199.8 mM)r
	Water: 100 mg/mL (199.8 mM)r
	Ethanol: <1 mg/mL
Solubility In Vivo	Chemical Name: N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride InChi Key: RJNSNFZXAZXOFX-UHFFFAOYSA-N InChi Code: InChI=1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H2,1-3H3,(H,25,29);2*1H SMILES Code: O=C(NC1=C(C)C=CC=C1C)CN2CCN(CC(O)COC3=CC=CC=C3OC)CC2.[H]Cl.[H]Cl
Synonyms	RS-43285; RS43285; RS 43285; CVT 303; CVT303; CVT-303; Ranolazine; Ranexa; Latixa; Ranolazine Dihydrochloride; Ranolazine Hydrochloride; Ranolazine HCl; .

Protocol	In Vivo	Ranolazine (Bolus injection 10 mg/kg and infusion 9.6 mg/kg/h; bolus injection; for 145 minutes; male Wistar rats) treatment significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion
	Animal model	Male Wistar rats (240-350 g)
	Dosages	Bolus injection 10 mg/kg and infusion (9.6 mg/kg/h)
	Administration	Bolus injection; for 145 minutes

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9982 mL	9.9908 mL	19.9816 mL	39.9632 mL
5mM	0.3996 mL	1.9982 mL	3.9963 mL	7.9926 mL
10mM	0.1998 mL	0.9991 mL	1.9982 mL	3.9963 mL
20mM	0.0999 mL	0.4995 mL	0.9991 mL	1.9982 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.