Felodipine (CGH869)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$290	Check With Us
5g	$850	Check With Us
10g	$1275	Check With Us

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Cat #: V0619 CAS #: 72509-76-3 Purity ≥ 98%

Description: Felodipine (formerly also known as CGH-869; trade names Plendil, Renedil etc.), a marketed anti-hypertensive drug, is a potent, selective and long-acting L-type Ca2+ channel blocker (CCB) of the 1,4-dihydropyridine (DHP) class with an IC50 of 0.15 nM.

References: Johnson JD, et al. Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther. 1983;226(2):330-334.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	384.25
Molecular Formula	C18H19Cl2NO4
CAS No.	72509-76-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 77 mg/mL (200.4 mM)r
	Water: <1 mg/mLr
	Ethanol: 77 mg/mL (200.4 mM)
Synonyms	CGH-869; Perfudal, Plendil, Renedil, Felodipine,CGH 869; Felobeta, CGH869; Agon, Felo-Puren,Felocor, Felodipin, Felodur Felogamma, Fensel, Flodil, Modip, Munobal,

Protocol	In Vitro	Felodipine, a dihydropyridine calcium antagonist, is the most potent in relaxing porcine coronary arteries (IC50=0.15 nM)

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6025 mL	13.0124 mL	26.0247 mL	52.0494 mL
5mM	0.5205 mL	2.6025 mL	5.2049 mL	10.4099 mL
10mM	0.2602 mL	1.3012 mL	2.6025 mL	5.2049 mL
20mM	0.1301 mL	0.6506 mL	1.3012 mL	2.6025 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.