GV-58

This product is for research use only, not for human use. We do not sell to patients.

GV-58
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Size Price Stock
50mg$1200Check With Us
100mg$1950Check With Us
200mg$2975Check With Us

Cat #: V32977 CAS #: 1402821-41-3 Purity ≥ 99%

Description: GV-58 is a pupin analog that acts as a novel, potent and selective agonist of N- and P/Q-type Ca2+ channels with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel.

References: Tarr TB, et al. Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome. J Neurosci. 2013 Jun 19;33(25):10559-67.

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Molecular Weight (MW)374.50
Molecular FormulaC₁₈H₂₆N₆OS
CAS No.1402821-41-3
SynonymsGV-58; GV 58; GV58
ProtocolIn VitroGV-58 (50 μM; 30 min) restores function in LEMS passive transfer neuromuscular junction
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6702 mL13.3511 mL26.7023 mL53.4045 mL
5mM0.5340 mL2.6702 mL5.3405 mL10.6809 mL
10mM0.2670 mL1.3351 mL2.6702 mL5.3405 mL
20mM0.1335 mL0.6676 mL1.3351 mL2.6702 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.