DHBP dibromide (Diheptylviologen dibromide)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $450 | Check With Us |
| 10g | $750 | Check With Us |
| 20g | $1125 | Check With Us |
: Cat #: V29906 CAS #: 6159-05-3 Purity ≥ 99%
Description: DHBP dibromide (Diheptylviologen dibromide) is a potent inhibitor for calcium release and a muscle relaxant.
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| Molecular Weight (MW) | 514.38 |
|---|---|
| Molecular Formula | C₂₄H₃₈Br₂N₂ |
| CAS No. | 6159-05-3 |
| SMILES Code | CCCCCCC[N+]1=CC=C(C2=CC=[N+](CCCCCCC)C=C2)C=C1.[Br-].[Br-] |
| Protocol | In Vitro | DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9441 mL | 9.7204 mL | 19.4409 mL | 38.8818 mL |
| 5mM | 0.3888 mL | 1.9441 mL | 3.8882 mL | 7.7764 mL |
| 10mM | 0.1944 mL | 0.9720 mL | 1.9441 mL | 3.8882 mL |
| 20mM | 0.0972 mL | 0.4860 mL | 0.9720 mL | 1.9441 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.