Amlodipine Besylate (Norvasc)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $260 | Check With Us |
| 10g | $470 | Check With Us |
| 20g | $705 | Check With Us |
: Cat #: V0349 CAS #: 111470-99-6 Purity ≥ 98%
Description: Amlodipine (formerly UK-48340; Norvasc; used as as besylate, mesylate or maleate salts) is a selective and long-acting CCB-calcium channel blocker that belongs to the dihydropyridine (DHP) class.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 567.05 |
|---|---|
| Molecular Formula | C20H25ClN2O5.C6H6O3S |
| CAS No. | 111470-99-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 113 mg/mL (199.3 mM)r |
| Water: < 1 mg/mLr | |
| Ethanol: 14 mg/mL (24.7 mM) | |
| Synonyms | UK 48340; Cordarene; UK-48340; UK48340; Amlodipine besylate; Cardiorex; |
| Protocol | In Vitro | Amlodipine besylate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively |
|---|---|---|
| In Vivo | Amlodipine besylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7635 mL | 8.8176 mL | 17.6351 mL | 35.2703 mL |
| 5mM | 0.3527 mL | 1.7635 mL | 3.5270 mL | 7.0541 mL |
| 10mM | 0.1764 mL | 0.8818 mL | 1.7635 mL | 3.5270 mL |
| 20mM | 0.0882 mL | 0.4409 mL | 0.8818 mL | 1.7635 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.