Tezacaftor (VX-661)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$945	Check With Us
500mg	$1450	Check With Us
1g	$2175	Check With Us

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Cat #: V1691 CAS #: 1152311-62-0 Purity ≥ 98%

Description: Tezacaftor (formerly VX-661; VX661; VX 661; trade name: Symdeko) is a second F508del CFTR corrector with antifibrotic effects and is also one of three components in the fixed-dose combination medication (cocktail: Elexacaftor/tezacaftor/ivacaftor, Trikafta and Kaftrio) used in patients who have cystic fibrosis with a F508del mutation.

References: Treatment with VX-661 and Ivacaftor in a Phase 2 Study Resulted in Statistically Significant Improvements in Lung Function in People with Cystic Fibrosis Who Have Two Copies of the F508del Mutation. April 18, 2013

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	520.5
Molecular Formula	C26H27F3N2O6
CAS No.	1152311-62-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (192.1 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	VX-661; Trikafta; VX661; VX 661.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9212 mL	9.6061 mL	19.2123 mL	38.4246 mL
5mM	0.3842 mL	1.9212 mL	3.8425 mL	7.6849 mL
10mM	0.1921 mL	0.9606 mL	1.9212 mL	3.8425 mL
20mM	0.0961 mL	0.4803 mL	0.9606 mL	1.9212 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.