Isoxazole 9 (ISX-9)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1150 | Check With Us |
| 1g | $1725 | Check With Us |
: Cat #: V1885 CAS #: 832115-62-5 Purity ≥ 98%
Description: Isoxazole 9 (also known as Isx-9) is a synthetic promotor/inducer of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs).
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| Molecular Weight (MW) | 234.27 |
|---|---|
| Molecular Formula | C11H10N2O2S |
| CAS No. | 832115-62-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 46 mg/mL (196.4 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 13 mg/mL (55.5 mM) | |
| Solubility In Vivo | 5% DMSO+55% PEG 300+ddH2O: 10mg/mL |
| Synonyms | ISX-9; ISX 9; ISX9; Isoxazole 9; Isoxazole-9 |
| Protocol | In Vitro | ISX-9 promotes neurogenesis in vivo, enhances proliferation and differentiation of subgranular hippocampal region (SGZ) neuroblasts, and dendritic differentiation of adult-produced dentate gyrus. At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis in adult rat hippocampal stem cells and block glial cell production through a calcium-activated signaling pathway dependent on muscle cell enhancement factor 2-dependent gene expression |
|---|---|---|
| In Vivo | ISX-9 (20 mg/kg； Lasts 12 days; mice) treatment improves hippocampal function. ISX-9 enhances spatial memory in the Morris Water Maze test. ISX-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are dependent on Mef2 |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.2686 mL | 21.3429 mL | 42.6858 mL | 85.3716 mL |
| 5mM | 0.8537 mL | 4.2686 mL | 8.5372 mL | 17.0743 mL |
| 10mM | 0.4269 mL | 2.1343 mL | 4.2686 mL | 8.5372 mL |
| 20mM | 0.2134 mL | 1.0671 mL | 2.1343 mL | 4.2686 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.