Clobetasol propionate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $280 | Check With Us |
| 5g | $500 | Check With Us |
| 10g | $750 | Check With Us |
: Cat #: V1714 CAS #: 25122-46-7 Purity ≥ 98%
Description: Clobetasol propionate (formerly CGP-9555, CCl-4725; CGP9555; CCl4725; Clobex Cosvate; Temovate; Olux Tenovate) is a topical corticosteroid used as an anti-inflammatory for treatment of various skin disorders including eczema and psoriasis.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 466.97 |
|---|---|
| Molecular Formula | C25H32ClFO5 |
| CAS No. | 25122-46-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 93 mg/mL (199.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 20 mg/mL (42.8 mM) | |
| Synonyms | CGP 9555; CCl 4725; CGP-9555; CCl-4725; CGP9555; CCl4725; Clobex Cosvate; Temovate; Olux Tenovate Dermovate; Dermatovate; Butavate; Movate Novate. |
| Protocol | In Vitro | Clobetasol propionate (1 μM; 24 hours) selectively inhibits CYP3A5 and does not increase the protein level of CYP3A4. Clobetasol propionate does not affect cell growth in any cell line (AsPC-1 wild-type (WT), AsPC-1CYP3A5–/– cells with CYP3A5 overexpression (“3A5–/– + 3A5OE” cells), and AsPC-1CYP3A5–/– cells with CYP3A4 overexpression (“3A5–/– + 3A4OE” cells)) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1415 mL | 10.7073 mL | 21.4147 mL | 42.8293 mL |
| 5mM | 0.4283 mL | 2.1415 mL | 4.2829 mL | 8.5659 mL |
| 10mM | 0.2141 mL | 1.0707 mL | 2.1415 mL | 4.2829 mL |
| 20mM | 0.1071 mL | 0.5354 mL | 1.0707 mL | 2.1415 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.