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Cav 2.2 blocker 1

This product is for research use only, not for human use. We do not sell to patients.

Cav 2.2 blocker 1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$1100In Stock
100mg$1900In Stock
200mg$2850In Stock
email: [email protected]        [email protected]

Cat #: V32590 CAS #: 1567335-29-8 Purity ≥ 98%

Description: Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM.

References: Wall MJ, et al. Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3780-3783.

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Molecular Weight (MW)424.96
Molecular FormulaC25H29ClN2O2
CAS No.1567335-29-8
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3532 mL11.7658 mL23.5316 mL47.0633 mL
5mM0.4706 mL2.3532 mL4.7063 mL9.4127 mL
10mM0.2353 mL1.1766 mL2.3532 mL4.7063 mL
20mM0.1177 mL0.5883 mL1.1766 mL2.3532 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.