C16 (PKR Inhibitor)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $550 | Check With Us |
| 250mg | $1000 | Check With Us |
| 500mg | $1500 | Check With Us |
: Cat #: V17398 CAS #: 608512-97-6 Purity ≥ 99%
Description: C16 (GW-506033X; C-16; PKR Inhibitor) is a brain penetrant protein kinase (PKR) inhibitor with anti-inflammatory effects.
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| Molecular Weight (MW) | 268.29 |
|---|---|
| Molecular Formula | C13H8N4OS |
| CAS No. | 608512-97-6 |
| SMILES Code | O=C1/C(C2=C(SC=N3)C3=CC=C2N1)=C\C4=CN=CN4 |
| Synonyms | GW-506033X; GW 506033X; GW506033X; C16, PKR Inhibitor |
| Protocol | In Vitro | PKR-IN-C16 (0.1 or 0.3 μM; 24 h) shows protective effect against the neuronal cell death induced by endoplasmic reticulum stress in SH-SY5Y cells. PKR-IN-C16 (Compound C16) is able to unlock the translation blockade induced by PKR in primary neuronal cultures. |
|---|---|---|
| In Vivo | PKR-IN-C16 (Compound C16) (60 or 600 μg/kg; i.p.; 3 times) prevents not only the PKR-induced neuronal loss but also the inflammatory response in the Quinolinic acid (QA) (HY-100807) induced acute excitotoxic rat model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7273 mL | 18.6366 mL | 37.2731 mL | 74.5462 mL |
| 5mM | 0.7455 mL | 3.7273 mL | 7.4546 mL | 14.9092 mL |
| 10mM | 0.3727 mL | 1.8637 mL | 3.7273 mL | 7.4546 mL |
| 20mM | 0.1864 mL | 0.9318 mL | 1.8637 mL | 3.7273 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.