Ibuprofen piconol (U75630)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $580 | Check With Us |
| 10g | $950 | Check With Us |
| 20g | $1425 | Check With Us |
: Cat #: V4883 CAS #: 64622-45-3 Purity ≥ 98%
Description: Ibuprofen piconol (U75630), the pyridyl ester of ibuprofen, is a potent non-steroidal, anti-inflammatory (NSAID) drug marketed in Japan for the topical relief of primary thermal burns and sunburns.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 297.39 |
|---|---|
| Molecular Formula | C19H23NO2 |
| CAS No. | 64622-45-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | CC(C1=CC=C(CC(C)C)C=C1)C(OCC2=NC=CC=C2)=O |
| Synonyms | Ibuprofen piconol |
| Protocol | In Vitro | Ibuprofen piconol is a chemically stable, slightly hygroscopic liquid that strongly partitions into the oil phase and shows no indication of surface activity. This drug has very limited solubility in water (16.5 ppm), modest solubility in glycerol (16.4 mg/mL), and is miscible with less polar organics except for silicone fluids. |
|---|---|---|
| In Vivo | When ibuprofen piconol is applied topically, only ibuprofen and its metabolites are observed in plasma and urine. The conversion of ibuprofen piconol to ibuprofen appears to be extremely rapid in vivo. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.3626 mL | 16.8129 mL | 33.6259 mL | 67.2518 mL |
| 5mM | 0.6725 mL | 3.3626 mL | 6.7252 mL | 13.4504 mL |
| 10mM | 0.3363 mL | 1.6813 mL | 3.3626 mL | 6.7252 mL |
| 20mM | 0.1681 mL | 0.8406 mL | 1.6813 mL | 3.3626 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.