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SAR191801

This product is for research use only, not for human use. We do not sell to patients.

SAR191801
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1250In Stock
500mg$1900In Stock
1g$2850In Stock
email: [email protected]        [email protected]

Cat #: V14333 CAS #: 1234708-04-3 Purity ≥ 98%

Description: SAR191801 (hPGDS-IN-1) is a novel, potent and selecive hPGDS inhibitor with an IC50 of 12 nM in the Fluorescence Polarization Assay (the EIA assay).  

References: Vandeusen, Christopher L, et al. Phenyloxadiazole derivatives as PGD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of allergic and inflammatory disorders. From PCT Int. Appl. (2011), WO 2011044307 A1 20110414.

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Molecular Weight (MW)416.43
Molecular FormulaC22H20N6O3
CAS No.1234708-04-3
SMILES CodeO=C(C1=CN=C(C2=NC=CC=C2)N=C1)NCC3=CC=CC(C4=NOC(C(C)(O)C)=N4)=C3
SynonymsSAR 191801; SAR-191801; SAR191801
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4014 mL12.0068 mL24.0136 mL48.0273 mL
5mM0.4803 mL2.4014 mL4.8027 mL9.6055 mL
10mM0.2401 mL1.2007 mL2.4014 mL4.8027 mL
20mM0.1201 mL0.6003 mL1.2007 mL2.4014 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.