MP-A08
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1300 | Check With Us |
| 1g | $2100 | Check With Us |
| 5g | $5315 | Check With Us |
: Cat #: V25815 CAS #: 219832-49-2 Purity ≥ 99%
Description: MP-A08 is a novel and potent sphingosine kinase inhibitor.
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| Molecular Weight (MW) | 519.64 |
|---|---|
| Molecular Formula | C27H25N3O4S2 |
| CAS No. | 219832-49-2 |
| SMILES Code | O=S(C1=CC=C(C)C=C1)(NC2=CC=CC=C2/C=N/C3=CC=CC=C3NS(=O)(C4=CC=C(C)C=C4)=O)=O |
| Synonyms | MP-A08; MP A08; MPA08; NSC-122314; NSC 122314; NSC122314; |
| Protocol | In Vitro | MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type. |
|---|---|---|
| In Vivo | MP-A08 suppresses the growth of human lung tumor xenografts in mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9244 mL | 9.6220 mL | 19.2441 mL | 38.4882 mL |
| 5mM | 0.3849 mL | 1.9244 mL | 3.8488 mL | 7.6976 mL |
| 10mM | 0.1924 mL | 0.9622 mL | 1.9244 mL | 3.8488 mL |
| 20mM | 0.0962 mL | 0.4811 mL | 0.9622 mL | 1.9244 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.