Senicapoc (ICA17043)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$450	Check With Us
500mg	$750	Check With Us
1g	$1125	Check With Us

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Cat #: V14637 CAS #: 289656-45-7 Purity ≥ 98%

Description: Senicapoc, formerly known as ICA-17043, is a highly potent Gardos Channel (Ca2+-activated K+ channel; KCa3.1) inhibitor/blocker with an IC50 of 11 nM, and with the potential for the treatment of a subset of Hereditary Xerocytosis caused by mutations in the Gardos channel.

References: Stocker JW, et al. ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003 Mar 15; 101(6):2412-8.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	323.34
Molecular Formula	C20H15F2NO
CAS No.	289656-45-7
SMILES Code	C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N

Protocol	In Vitro	ICA-17043 shows Gardos channel that blocks RBCs in mice (C57 black), IC50 is 50±6 nM. ICA-17043 Prevents an increase in cellular hemoglobin concentration in human erythrocytes in a concentration-dependent manner
Protocol	In Vivo	ICA-17043 (10 mg/kg, oral) Gardos channel activity measured on days 11 and 21 after administration was significantly reduced and correlated with a corresponding increase in erythrocyte K content, while there was no change in Na content. ICA-17043 (10 mg/kg twice daily) induces a significant increase in Hct after 11 days of administration in mice with SAD++

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0927 mL	15.4636 mL	30.9272 mL	61.8544 mL
5mM	0.6185 mL	3.0927 mL	6.1854 mL	12.3709 mL
10mM	0.3093 mL	1.5464 mL	3.0927 mL	6.1854 mL
20mM	0.1546 mL	0.7732 mL	1.5464 mL	3.0927 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.