SKA-31
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $500 | To Be Confirmed |
| 250mg | $950 | To Be Confirmed |
| 500mg | $1425 | To Be Confirmed |
: Cat #: V14863 CAS #: 40172-65-4 Purity ≥ 99%
Description: SKA-31 is a novel and potent activator of KCa2 and KCa3.1 calcium-activated potassium channels with blood pressure-lowering effects.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 200.259 |
|---|---|
| Molecular Formula | C11H8N2S |
| CAS No. | 40172-65-4 |
| Synonyms | SKA31; SKA 31 |
| Protocol | In Vitro | SKA-31 activates KCa2/3 channels more potently than PK 26124, and is more selective over other Ion channels |
|---|---|---|
| In Vivo | SKA-31 potentiates native KCa3.1 and KCa2.3 in murine carotid endothelium with EC50 values of 225 nM and 1.6 μM for KCa3.1 and KCa2.3, respectively | |
| Animal model | 16-25 weeks mice | |
| Dosages | 1 mg/kg, 10 mg/kg, and 30 mg/kg | |
| Administration | Intraperitoneal injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.9935 mL | 24.9677 mL | 49.9353 mL | 99.8707 mL |
| 5mM | 0.9987 mL | 4.9935 mL | 9.9871 mL | 19.9741 mL |
| 10mM | 0.4994 mL | 2.4968 mL | 4.9935 mL | 9.9871 mL |
| 20mM | 0.2497 mL | 1.2484 mL | 2.4968 mL | 4.9935 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.