Simvastatin ammonium salt
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | To Be Confirmed |
| 500mg | $750 | To Be Confirmed |
| 1g | $1125 | To Be Confirmed |
: Cat #: V14807 CAS #: 139893-43-9 Purity ≥ 99%
Description: Simvastatin ammonium salt is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver, acting as an inhibitor of HMG-CoA reductase.
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| Molecular Weight (MW) | 453.61 |
|---|---|
| Molecular Formula | C25H43NO6 |
| CAS No. | 139893-43-9 |
| SMILES Code | O=C([O-])C[C@H](O)C[C@H](O)CC[C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@H](OC(C(C)(C)CC)=O)[C@]12[H].[NH4+] |
| Synonyms | Simvastatin ammonium salt; Synvinolin; MK-733; Sinvacor; MK 733; MK-733; MK733; |
| Protocol | In Vitro | Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2045 mL | 11.0227 mL | 22.0454 mL | 44.0907 mL |
| 5mM | 0.4409 mL | 2.2045 mL | 4.4091 mL | 8.8181 mL |
| 10mM | 0.2205 mL | 1.1023 mL | 2.2045 mL | 4.4091 mL |
| 20mM | 0.1102 mL | 0.5511 mL | 1.1023 mL | 2.2045 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.