Riboflavin Tetrabutyrate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50g	$450	Check With Us
100g	$750	Check With Us
200g	$1125	Check With Us

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Cat #: V29430 CAS #: 752-56-7 Purity ≥ 99%

Description: Riboflavin Tetrabutyrate is a lipophilic analogue of Riboflavin (vitamin B2), which is a vitamin B and an important nutrient that plays a key role in maintaining health in humans and other animals.

References: Tahara K, et al. Effect of riboflavin and riboflavin 2',3',4',5'-tetrabutyrate on rat liver microsomallipid peroxidation. J Nutr Sci Vitaminol (Tokyo). 1974;20(2):81-8.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	656.72
Molecular Formula	C33H44N4O10
CAS No.	752-56-7
SMILES Code	O=C([C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O)[C@@H](C)C([C@@H](C)C(O[C@H](CC)[C@@]2(C)O3)=O)=O)[C@H](C)[C@@]2([H])N(CCCCN4C=C(C5=CC=CN=C5)N=C4)C3=O
Synonyms	Telithromycin; HMR-3647; HMR 3647; HMR3647; RU-66647; RU 66647; RU66647

Protocol	In Vitro	Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction.
Protocol	In Vivo	Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevated serum lipid.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5227 mL	7.6136 mL	15.2272 mL	30.4544 mL
5mM	0.3045 mL	1.5227 mL	3.0454 mL	6.0909 mL
10mM	0.1523 mL	0.7614 mL	1.5227 mL	3.0454 mL
20mM	0.0761 mL	0.3807 mL	0.7614 mL	1.5227 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.