GW-870086
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1080 | To Be Confirmed |
| 500mg | $1550 | To Be Confirmed |
| 1g | $2325 | To Be Confirmed |
: Cat #: V4929 CAS #: 827319-43-7 Purity ≥ 98%
Description: GW-870086 is a novel and potent glucocorticoid receptor agonist that has anti-inflammatory properties, and thus can be potentially usef for the treatment of asthma and atopic dermatitis..
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 559.64 |
|---|---|
| Molecular Formula | C31H39F2NO6 |
| CAS No. | 827319-43-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | C[C@@]12[C@](C(OCC#N)=O)(OC(C3C(C)(C)C3(C)C)=O)[C@H](C)C[C@@]1([H])[C@]4([H])C[C@H](F)C5=CC(C=C[C@]5(C)[C@@]4(F)[C@@H](O)C2)=O |
| Synonyms | GW870086; GW870086X; GW 870086; GW 870086X; GW-870086; GW-870086X; 870086; |
| Protocol | In Vitro | GW-870086 a glucocorticoid receptor agonist, inhibits NFkB reporter gene with a pIC50 of 10.1, but shows no effect on the MMTV reporter genes in A549 cells, and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor or androgen receptor. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7869 mL | 8.9343 mL | 17.8686 mL | 35.7373 mL |
| 5mM | 0.3574 mL | 1.7869 mL | 3.5737 mL | 7.1475 mL |
| 10mM | 0.1787 mL | 0.8934 mL | 1.7869 mL | 3.5737 mL |
| 20mM | 0.0893 mL | 0.4467 mL | 0.8934 mL | 1.7869 mL |
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.