Clobetasone Butyrate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $450 | Check With Us |
| 5g | $750 | Check With Us |
| 10g | $1125 | Check With Us |
: Cat #: V18495 CAS #: 25122-57-0 Purity ≥ 99%
Description: Clobetasone Butyrate (SN203; Emovate; SN-203; Eumovate; Cloptison; Molivate), the 17-O-butyl ester of Clobetasone, is a corticosteroid that has been used in dermatology for the treatment of skin inflammation such as eczema, psoriasis.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 478.98 |
|---|---|
| Molecular Formula | C26H32ClFO5 |
| CAS No. | 25122-57-0 |
| SMILES Code | C[C@@]1(C2)[C@](C(CCl)=O)(OC(CCC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)C2=O)=O |
| Synonyms | Clobetasone Butyrate; Clobetasone 17-butyrate; SN203; SN-203; SN 203; Cloptison; Emovate; Eumovate; GR 2/1214; Molivat |
| Protocol | In Vitro | Clobetasone butyrate (application on the skin; 0.05%; 7 weeks) induces epidermal thinning in skin, Clobetasone butyrate 7 weeks causes much less epidermal thinning in the pig than flurandrenolone (0.05%) or fluocinolone acetonide (0.025%), both of which causes severe atrophy. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0878 mL | 10.4388 mL | 20.8777 mL | 41.7554 mL |
| 5mM | 0.4176 mL | 2.0878 mL | 4.1755 mL | 8.3511 mL |
| 10mM | 0.2088 mL | 1.0439 mL | 2.0878 mL | 4.1755 mL |
| 20mM | 0.1044 mL | 0.5219 mL | 1.0439 mL | 2.0878 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.