Tiagabine | CAS 115103-54-3

Tiagabine

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$350	Check With Us
500mg	$525	Check With Us
1g	$785	Check With Us

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Cat #: V33761 CAS #: 115103-54-3 Purity ≥ 99%

Description: Tiagabine (NO329; NNC-050328; NO 329; NNC-05-0328; NO-05-0328; trade name Gabitril) is a selective and potent GABA (gamma-aminobutyric acid) reuptake inhibitor with anti-convulsive activity.

References: Braestrup C, et al. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54(2):639-47.

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Molecular Weight (MW)	375.55
Molecular Formula	C₂₀H₂₅NO₂S₂
CAS No.	115103-54-3
SMILES Code	CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C.Cl
Synonyms	NO-329; NNC05-0328; NO329; NNC-050328; NO 329; NNC-05-0328; NO-05-0328

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6628 mL	13.3138 mL	26.6276 mL	53.2552 mL
5mM	0.5326 mL	2.6628 mL	5.3255 mL	10.6510 mL
10mM	0.2663 mL	1.3314 mL	2.6628 mL	5.3255 mL
20mM	0.1331 mL	0.6657 mL	1.3314 mL	2.6628 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.