Etomidate (R-16659)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $530 | Check With Us |
| 2g | $850 | Check With Us |
| 5g | $1350 | Check With Us |
: Cat #: V1285 CAS #: 33125-97-2 Purity ≥ 98%
Description: Etomidate (Amidate, Ethomidate, Hypnomidate, R-26490, R26490, Radenarkon), discovered at Janssen Pharmaceutica in 1964, is a GABAA receptor agonist that has been approved for use as a short-acting anaesthetic drug or sedative.
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| Molecular Weight (MW) | 244.29 |
|---|---|
| Molecular Formula | C14H16N2O2 |
| CAS No. | 33125-97-2 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 49 mg/mL (200.6 mM)rr |
| Water: <1 mg/mL 49rr | |
| Ethanol: 49 mg/mL (200.6 mM) | |
| Solubility In Vivo | Chemical Name: ethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate InChi Key: NPUKDXXFDDZOKR-LLVKDONJSA-N InChi Code: InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 SMILES Code: O=C(C1=CN=CN1[C@@H](C2=CC=CC=C2)C)OCC |
| Synonyms | R 26490, Etomidate, Amidate, Ethomidate, Hypnomidate, R-26490, R26490, Radenarkon |
| Protocol | In Vitro | Etomidate (R 16659) is a potent inhibitor of adrenal response to surgery. There are no clinical consequences associated with unresponsiveness that suggest that a large increase in adrenal hormone production may not be necessary during surgery |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.0935 mL | 20.4675 mL | 40.9350 mL | 81.8699 mL |
| 5mM | 0.8187 mL | 4.0935 mL | 8.1870 mL | 16.3740 mL |
| 10mM | 0.4093 mL | 2.0467 mL | 4.0935 mL | 8.1870 mL |
| 20mM | 0.2047 mL | 1.0234 mL | 2.0467 mL | 4.0935 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.