Esomeprazole magnesium (S-Omeprazole magnesium)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$470	Check With Us
10g	$2150	Check With Us
20g	$3225	Check With Us

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Cat #: V1635 CAS #: 161973-10-0 Purity ≥ 98%

Description: Esomeprazole Magnesium (S-Omeprazole magnesium; Nexium; H 168/68), the magnesium salt of esomeprazole, is S-isomer of omeprazole which is a proton pump inhibitor (PPI) that has been approved for reducing gastric acid secretion (e.g. acid reflux, ulcers).

References: Timothy R Koch, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep;15(9):522-6.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	713.12
Molecular Formula	C34H36MgN6O6S2
CAS No.	161973-10-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 143 mg/mL (200.5 mM)r
	Water:<1 mg/mLr
	Ethanol: 143 mg/mL (200.5 mM)
Synonyms	Esomeprazole Magnesium; Omeprazole magnesium; Nexium; H 168/68 magnesium

Protocol	In Vivo	Esomeprazole magnesium (0.5-50 mg/kg; oral gavage; daily; for 10 days; A/J mice) treatment increases gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity
	Animal model	A/J mice
	Dosages	0.5 mg/kg, 5 mg/kg, 50 mg/kg
	Administration	Oral gavage; daily; for 10 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.4023 mL	7.0114 mL	14.0229 mL	28.0458 mL
5mM	0.2805 mL	1.4023 mL	2.8046 mL	5.6092 mL
10mM	0.1402 mL	0.7011 mL	1.4023 mL	2.8046 mL
20mM	0.0701 mL	0.3506 mL	0.7011 mL	1.4023 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.