Dexlansoprazole (R-Lansoprazole)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$250	Check With Us
5g	$700	Check With Us
10g	$1050	Check With Us

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Cat #: V1638 CAS #: 138530-94-6 Purity ≥ 98%

Description: Dexlansoprazole (formerly known as T168390; TAK390; Kapidex; Dexilant, R-Lansoprazole and TAK-390MR), the dextrorotatory or R-enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties by employing a novel release formulation that prolongs its absorption.

References: Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48(5): p. 391-5.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	369.36
Molecular Formula	C16H14F3N3O2S
CAS No.	138530-94-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 74 mg/mL (200.3 mM)r
	Water:<1 mg/mLr
	Ethanol: 74 mg/mL (200.3 mM)
Synonyms	T-168390; TAK-390MR; TAK-390; T168390; TAK390; T 168390; TAK 390; Dexlansoprazole; Dexilant; Kapidex; TAK 390MR; TAK390MR

Protocol	In Vitro	The plasma concentrations of (R)-lansoprazole are remarkably higher in all three CYP2C19 genotype groups than those of the corresponding (S)-enantiomer. The AUC0-∞ Cmax and elimination half-life of (R)-lansoprazole are significantly greater and longer, respectively, than those of the (S)-enantiomer for all three genotype groups

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7074 mL	13.5369 mL	27.0739 mL	54.1477 mL
5mM	0.5415 mL	2.7074 mL	5.4148 mL	10.8295 mL
10mM	0.2707 mL	1.3537 mL	2.7074 mL	5.4148 mL
20mM	0.1354 mL	0.6768 mL	1.3537 mL	2.7074 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.