Tenatoprazole (TU-199)

This product is for research use only, not for human use. We do not sell to patients.

Tenatoprazole (TU-199)
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Size Price Stock
500mg$450Check With Us
1g$650Check With Us
5g$1755Check With Us

Cat #: V1640 CAS #: 113712-98-4 Purity ≥ 98%

Description: Tenatoprazole (formerly known as TU-199; TU 199; Ulsacare; Protop) is a prodrug of the proton pump inhibitor (PPI) class with the potential for the treatment of gastroesophageal reflux disease.

References: Uchiyama K, et al. The long-lasting effect of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion in dogs. J Pharm Pharmacol. 1999;51(4):457-464.

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Molecular Weight (MW)346.4
Molecular FormulaC16H18N4O3S
CAS No.113712-98-4
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 46 mg/mL (132.8 mM)r
Water:<1 mg/mLr
Ethanol: 14 mg/mL (40.4 mM)
SynonymsTU199; Tenatoprazole; TU-199; TU 199; Ulsacare; Protop
ProtocolIn VitroTenatoprazole (TU-199) (0.1, 0.2, 0.4 mg/kg; oral; single; Heidenhain-pouch dogs) dose-dependently suppresses gastric acid secretion stimulated by histamine infusion
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.8868 mL14.4342 mL28.8684 mL57.7367 mL
5mM0.5774 mL2.8868 mL5.7737 mL11.5473 mL
10mM0.2887 mL1.4434 mL2.8868 mL5.7737 mL
20mM0.1443 mL0.7217 mL1.4434 mL2.8868 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.