Gap 27
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $750 | Check With Us |
| 100mg | $1250 | Check With Us |
| 200mg | $1875 | Check With Us |
: Cat #: V31969 CAS #: 198284-64-9 Purity ≥ 99%
Description: Gap 27 is a connexin43 peptide derivative that acts as a novel and potent gap junction inhibitor.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 1304.53 |
|---|---|
| Molecular Formula | C₆₀H₁₀₁N₁₅O₁₇ |
| CAS No. | 198284-64-9 |
| Synonyms | Gap27; Gap-27; Gap 27 |
| Protocol | In Vitro | Gap 27 causes a remarked decrease in the number of both TRAP-positive mononuclear and multinucleated rat osteoclasts cultured on bovine bone slices. The activity of the remaining osteoclasts is found to be diminished by measuring the percentage of osteoclasts with actin rings of all TRAP-positive cells. In addition, the resorbed area in the treated cultures is greatly diminished |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.7666 mL | 3.8328 mL | 7.6656 mL | 15.3312 mL |
| 5mM | 0.1533 mL | 0.7666 mL | 1.5331 mL | 3.0662 mL |
| 10mM | 0.0767 mL | 0.3833 mL | 0.7666 mL | 1.5331 mL |
| 20mM | 0.0383 mL | 0.1916 mL | 0.3833 mL | 0.7666 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.