ML-7 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $779 | To Be Confirmed |
| 500mg | $1250 | To Be Confirmed |
| 1g | $1875 | To Be Confirmed |
: Cat #: V4009 CAS #: 110448-33-4 Purity ≥ 98%
Description: ML-7 hydrochloride (HCl), a novel naphthalene sulphonamide derivative, is a novel potent inhibitor of Myosin light chain kinase (MLCK) with anticancer effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 452.74 |
|---|---|
| Molecular Formula | C15H18ClIN2O2S |
| CAS No. | 110448-33-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 40mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=S(N1CCNCCC1)(C2=C3C=CC=C(I)C3=CC=C2)=O.[H]Cl |
| Synonyms | ML-7 HCl; ML-7 hydrochloride; ML7. |
| Protocol | In Vivo | In sham animals, Evans blue extravasation differed between ML-7 hydrochloride and vehicle groups (sham + vector: 0.26±0.02 OD/g; False + ML-7 hydrochloride: 0.26±0.02 OD/g). After inhibition of MLCK with ML-7 hydrochloride, CCI inhibition of MLCK resulted in a significant reduction in the amount of Evans blue in the brain compared with vehicle-treated animals (CCI+ medium: 0.42±0.04 OD/g; CCI+ ML-7 hydrochloride：0.35±0.05 OD/g，p =0.048) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2088 mL | 11.0439 mL | 22.0877 mL | 44.1755 mL |
| 5mM | 0.4418 mL | 2.2088 mL | 4.4175 mL | 8.8351 mL |
| 10mM | 0.2209 mL | 1.1044 mL | 2.2088 mL | 4.4175 mL |
| 20mM | 0.1104 mL | 0.5522 mL | 1.1044 mL | 2.2088 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.