AZ 3146
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1150 | Check With Us |
| 1g | $1750 | Check With Us |
| 5g | $4725 | Check With Us |
: Cat #: V1628 CAS #: 1124329-14-1 Purity ≥ 98%
Description: AZ3146 (AZ-3146; AZ3146) is a novel, potent and selective Mps1 kinase (Monopolar spindle1) inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 452.55 |
|---|---|
| Molecular Formula | C24H32N6O3 |
| CAS No. | 1124329-14-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 28 mg/mL (61.9 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 91 mg/mL (201.1 mM) | |
| Synonyms | AZ3146; AZ 3146; AZ-3146 |
| Protocol | In Vitro | In in vitro kinase assays, AZ3146 inhibits human Mps1Cat with IC50 of ~35 nM. AZ3146 also efficiently inhibits autophosphorylation of full-length Mps1 immunoprecipitated from human cells |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2097 mL | 11.0485 mL | 22.0970 mL | 44.1940 mL |
| 5mM | 0.4419 mL | 2.2097 mL | 4.4194 mL | 8.8388 mL |
| 10mM | 0.2210 mL | 1.1049 mL | 2.2097 mL | 4.4194 mL |
| 20mM | 0.1105 mL | 0.5524 mL | 1.1049 mL | 2.2097 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.