Tirofiban (L700462; MK383)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $700 | Check With Us |
| 500mg | $1200 | Check With Us |
| 1g | $1800 | Check With Us |
: Cat #: V1599 CAS #: 144494-65-5 Purity ≥ 98%
Description: Tirofiban (formerly known as L-700462; MK-383; L700462; MK383; Aggrastat) is a novel non-peptide antagonist of glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) that has been approved for use as an antiplatelet drug.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 440.6 |
|---|---|
| Molecular Formula | C22H36N2O5S |
| CAS No. | 144494-65-5 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLrr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Synonyms | MK-383 Hydrochloride; Aggrastat; L-700462; MK-383; L 700462; MK 383; L700462; L-700,462; MK383 |
| Protocol | In Vivo | Tirofiban (60 μg/kg； Intravenous injection; Once) showed activity to increase contractility, ventricular compliance, and improve cardiac function by increasing HR, LVESP, dp/dtmax, and decreasing LVEDP |
|---|---|---|
| Animal model | Male Sprague-Dawley rats (10 to 15-week-age; 270-330 g) | |
| Dosages | 60 μg/kg | |
| Administration | Intravenous injection; once. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2696 mL | 11.3482 mL | 22.6963 mL | 45.3926 mL |
| 5mM | 0.4539 mL | 2.2696 mL | 4.5393 mL | 9.0785 mL |
| 10mM | 0.2270 mL | 1.1348 mL | 2.2696 mL | 4.5393 mL |
| 20mM | 0.1135 mL | 0.5674 mL | 1.1348 mL | 2.2696 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.