ATN-161 (Ac-PHSCN-NH2)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1050 | Check With Us |
| 500mg | $1750 | Check With Us |
| 1g | $2625 | Check With Us |
: Cat #: V2794 CAS #: 262438-43-7 Purity ≥ 98%
Description: ATN-161 is a novel and potent small peptide inhibitor of the integrin α5β1, it inhibits the angiogenesis and growth of liver metastases in a murine model.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 597.64 |
|---|---|
| Molecular Formula | C23H35N9O8S |
| CAS No. | 262438-43-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: > 10 mMr |
| Water: 13 mg/mL (21.75 mM)r | |
| Ethanol: N/A | |
| SMILES Code | O=C(N)[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]1N(C(C)=O)CCC1)=O)CC2=CN= CN2)=O)CO)=O)CS)=O)CC(N)=O |
| Synonyms | AcPHSCNNH2; ATN161; ATN 161; ATN-161 |
| Protocol | In Vitro | The combination of ATN-161 plus 5-FU significantly reduces tumor cell proliferation compared to control and single-agent therapy (p<0.01). In addition, combination therapy leads to a significant increase of apoptotic (TUNEL-positive) tumor cells (p<0.03), whereas single-agent therapy does not increase in TUNEL-positive tumor cells. ATN-161 treatment leads to a significant reduction in EC number (21% decrease) after a 48 hr incubation time compared to control (p<0.03) |
|---|---|---|
| In Vivo | The preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) show that treatment with ATN-161 significantly reduces tumor weight and vessel density |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6732 mL | 8.3662 mL | 16.7325 mL | 33.4650 mL |
| 5mM | 0.3346 mL | 1.6732 mL | 3.3465 mL | 6.6930 mL |
| 10mM | 0.1673 mL | 0.8366 mL | 1.6732 mL | 3.3465 mL |
| 20mM | 0.0837 mL | 0.4183 mL | 0.8366 mL | 1.6732 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.