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Cilengitide TFA (EMD 121974)

This product is for research use only, not for human use. We do not sell to patients.

Cilengitide TFA (EMD 121974)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$845Check With Us
500mg$1350Check With Us
1g$2025Check With Us
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Cat #: V1596 CAS #: 199807-35-7 Purity ≥ 98%

Description: Cilengitide TFA (also known as EMD 121974; NSC-707544; EMD-85189; D-03497), the trifluoroacetic acid salt of cilengitide, is a highly potent and selective integrin inhibitor for the αvβ3 receptor and the αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; it showed ~10-fold selectivity against gpIIbIIIa.

References: Kim YH, et al. Combination therapy of cilengitide with belotecan against experimental glioblastoma. Int J Cancer. 2013 Aug 1;133(3):749-56.

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Molecular Weight (MW)702.68
Molecular FormulaC29H41F3N8O9
CAS No.199807-35-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 100 mg/mL (142.3 mM)r
Water: 8 mg/mL (11.4 mM)r
Ethanol: <1 mg/mL
Solubility In Vivo30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SynonymsEMD 121974; NSC-707544; EMD-85189; D-03497; EMD-121974; EMD121974; NSC 707544; EMD 85189; NSC707544; EMD85189; D03497; D 03497
ProtocolIn VitroIn vitro treatment of Cilengitide, at a concentration greater than 1 µM, shows concentration- and time-dependent cytotoxic effects
In VivoIn nude mice bearing M21-L melanoma tumors, Cilengitide dose i.p. at 10, 50, and 250 μg three times per week demonstrate inhibition of tumor growth with a reduction in both tumor volume (55%, 75%, and 89%, respectively) and tumor weight (23%, 38%, and 61%, respectively), when compared to controls
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.4231 mL7.1156 mL14.2312 mL28.4625 mL
5mM0.2846 mL1.4231 mL2.8462 mL5.6925 mL
10mM0.1423 mL0.7116 mL1.4231 mL2.8462 mL
20mM0.0712 mL0.3558 mL0.7116 mL1.4231 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.