ATN-161 TFA
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1160 | Check With Us |
| 500mg | $1850 | Check With Us |
| 1g | $2775 | Check With Us |
: Cat #: V0434 CAS #: 904763-27-5 Purity ≥ 99%
Description: ATN-161 TFA, the trifluoroacetic acid salt of ATN161, is a novel and potent small peptide inhibitor of the integrin α5β1 with potential anticancer activity.
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| Molecular Weight (MW) | 711.67 |
|---|---|
| Molecular Formula | C25H36F3N9O10S |
| CAS No. | 904763-27-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: > 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| Synonyms | AcPHSCNNH2; ATN161; ATN 161; ATN-161 |
| Protocol | In Vitro | The combination of ATN-161 trifluoroacetate salt plus 5-FU significantly reduced tumor cell proliferation compared to control and monotherapy (p<0.01). In addition, combination treatment resulted in a significant increase in apoptosis (TUNEL-positive) tumor cells (p<0.03), whereas monotherapy did not increase TUNEL-positive tumor cells. After 48 h of incubation, ATN-161 trifluoroacetate salt treatment resulted in a significant reduction in the number of ECs (21% reduction) (p<0.03) compared to the control |
|---|---|---|
| In Vivo | Preliminary experiments with α5β1-negative human colon cancer xenografts (HT29) have shown that treatment with ATN-161 trifluoroacetate salt significantly reduces tumor weight and vascular density |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.4051 mL | 7.0257 mL | 14.0515 mL | 28.1029 mL |
| 5mM | 0.2810 mL | 1.4051 mL | 2.8103 mL | 5.6206 mL |
| 10mM | 0.1405 mL | 0.7026 mL | 1.4051 mL | 2.8103 mL |
| 20mM | 0.0703 mL | 0.3513 mL | 0.7026 mL | 1.4051 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.