GLPG0187
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1150 | Check With Us |
| 250mg | $1750 | Check With Us |
| 500mg | $2625 | Check With Us |
: Cat #: V21632 CAS #: 1320346-97-1 Purity ≥ 98%
Description: GLPG0187 (GLPG-0187) is a novel, potent, broad spectrum and small molecule integrin receptor antagonist (IRA) with potential anticancer activity, inhibiting αvβ1-integrin with an IC50 of 1.3 nM.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 595.71 |
|---|---|
| Molecular Formula | C29H37N7O5S |
| CAS No. | 1320346-97-1 |
| SMILES Code | O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC=C(OC)C=C5)=O |
| Protocol | In Vitro | In solid-phase analysis, GLPG0187 is selective for several RGD integrinin receptors and αvβ's IC50 They are 1.3, 3.7, 2.0, 1.4, 1.2, and 7.7 nM, respectively 1，αvβ3，αvβ5，αvβ6，αvβ8，α5β1。 GLPG0187 is a potent inhibitor of osteoclast bone resorption and angiogenesis. Treatment with GLPG0187 increases the E-cadherin/wave protein ratio in a dose-dependent manner, resulting in cells presenting a more epithelial, sessile phenotype. GLPG0187 reduces the size of the high subpopulation of acetaldehyde dehydrogenase in prostate cancer cells in a dose-dependent manner |
|---|---|---|
| In Vivo | Block α via GLPG0187v- Integrin significantly reduces the growth of its metastatic tumors. The burden of bone tumors was significantly reduced, and bone metastasis/number of mice was significantly inhibited. The progression of bone metastasis and the formation of new bone metastases were significantly inhibited during treatment |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6787 mL | 8.3933 mL | 16.7867 mL | 33.5734 mL |
| 5mM | 0.3357 mL | 1.6787 mL | 3.3573 mL | 6.7147 mL |
| 10mM | 0.1679 mL | 0.8393 mL | 1.6787 mL | 3.3573 mL |
| 20mM | 0.0839 mL | 0.4197 mL | 0.8393 mL | 1.6787 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.