Lifitegrast (SAR 1118; SHP-606)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1150 | Check With Us |
| 1g | $1725 | Check With Us |
: Cat #: V34110 CAS #: 1025967-78-5 Purity ≥ 99%
Description: Lifitegrast (formerly SAR 1118; SAR 1118-023; SAR-1118; trade name Xiidra) is a novel and potent integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist approved in 2016 for the the treatment of Dry Eye Disease.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 615.48 |
|---|---|
| Molecular Formula | C₂₉H₂₄Cl₂N₂O₇S |
| CAS No. | 1025967-78-5 |
| Synonyms | SAR 1118; SAR 1118-023; SAR-1118; SHP-606; SAR1118-02; SHP606; SAR 1118; SHP 606; <span id="xn_c_prodv_37_conT1_t">SAR1118; Lifitegrast sodium; SAR-1118-023; Xiidra |
| Protocol | In Vitro | Lifitegrast (SAR 1118) inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6247 mL | 8.1237 mL | 16.2475 mL | 32.4950 mL |
| 5mM | 0.3249 mL | 1.6247 mL | 3.2495 mL | 6.4990 mL |
| 10mM | 0.1625 mL | 0.8124 mL | 1.6247 mL | 3.2495 mL |
| 20mM | 0.0812 mL | 0.4062 mL | 0.8124 mL | 1.6247 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.