Mdivi-1 (Mitochondrial division inhibitor 1)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$500	In Stock
500mg	$850	In Stock
1g	$1275	In Stock

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Cat #: V1591 CAS #: 338967-87-6 Purity ≥ 98%

Description: Mdivi-1 (Mitochondrial Division Inhibitor 1; Mdivi 1; Mdivi1) is a potent selective and cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with the potential for treating stroke, myocardial infarction, and neurodegenerative disease.

References: Cassidy-Stone A, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb;14(2):193-204.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	353.22
Molecular Formula	C15H10Cl2N2O2S
CAS No.	338967-87-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 70 mg/mL (198.2 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	5% DMSO+40% PEG 300+ddH2O: 7mg/mL
Synonyms	Mdivi-1; Mitochondrial Division Inhibitor 1; Mdivi 1; Mdivi1. Chemical Name: 3-(2,4-dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one SMILES Code: O=C1N(C2=CC(OC)=C(Cl)C=C2Cl)C(NC3=C1C=CC=C3)=S Exact Mass: 351.984

Protocol	In Vitro	Mdivi-1 inhibits Dnm1 GTPase activity in a dose-dependent manner, estimated EC50 1-10 μM. Mdivi-1 increases the apparent K of GTP0.5to reduce the apparent V of GTP hydrolysis.max, and results in the GTP Hill coefficient increase reaction observed in Dnm1 GTP hydrolysis
Protocol	In Vivo	The mitochondrial division DRP, Dnm1, is a target for mdivi-1 in vivo. Mdivi-1 quantitatively blocks GMPPCP-dependent Dnm1 self-assembly at concentrations similar to its effect on mitochondrial division in vivo

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.8311 mL	14.1555 mL	28.3110 mL	56.6219 mL
5mM	0.5662 mL	2.8311 mL	5.6622 mL	11.3244 mL
10mM	0.2831 mL	1.4155 mL	2.8311 mL	5.6622 mL
20mM	0.1416 mL	0.7078 mL	1.4155 mL	2.8311 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.