Deucravacitinib (BMS-986165)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$950	In Stock
250mg	$1700	In Stock
500mg	$2550	In Stock

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Cat #: V4752 CAS #: 1609392-27-9 Purity ≥ 98%

Description: Deucravacitinib (formerly BMS986165; BMS-986165; Tyk2-IN-4; Sotyktu) is a first-in-class, highly potent, orally bioavailable, selective and allosteric inhibitor of TYK2 (tyrosine kinase 2, a JAK family member/enzyme) in Phase 3 clinical studies across multiple immune-mediated diseases such as psoriatic arthritis, lupus and inflammatory bowel disease.

References: Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	425.46
Molecular Formula	C20H19D3N8O3
CAS No.	1609392-27-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[2H]
Synonyms	BMS-986165; BMS 986165; BMS986165; Deucravacitinib

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3504 mL	11.7520 mL	23.5040 mL	47.0079 mL
5mM	0.4701 mL	2.3504 mL	4.7008 mL	9.4016 mL
10mM	0.2350 mL	1.1752 mL	2.3504 mL	4.7008 mL
20mM	0.1175 mL	0.5876 mL	1.1752 mL	2.3504 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.