Omaveloxolone (RTA-408)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$945	In Stock
500mg	$1550	In Stock
1g	$2325	In Stock

: [email protected] [email protected]

Cat #: V1891 CAS #: 1474034-05-3 Purity ≥ 98%

Description: Omaveloxolone (formerly known as RTA-408; Skyclarys; RTA408), an antioxidant inflammation modulator (AIM), is a 2nd generation member of the synthetic triterpenoid that can activate Nrf2 (a cytoprotective transcription factor) and inhibit NF-κB signaling.

References: Probst BL, et al. RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity. PLoS One. 2015 Apr 21;10(4):e0122942.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	554.71
Molecular Formula	C33H44F2N2O3
CAS No.	1474034-05-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (180.3 mM)r
	Water: <1 mg/mLr
	Ethanol: 20 mg/mL (36.1 mM)
Solubility In Vivo	10%DMSO+90% Corn oil: 30mg/mL
SMILES Code	CC(F)(F)C(N[C@]1(CCC(C)(C[C@@]1([C@]23[H])[H])C)CC[C@@]2(C)[C@]4(C)CCC5C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O)=O
Synonyms	RTA 408; Skyclarys; RTA408; RTA-408

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8027 mL	9.0137 mL	18.0274 mL	36.0549 mL
5mM	0.3605 mL	1.8027 mL	3.6055 mL	7.2110 mL
10mM	0.1803 mL	0.9014 mL	1.8027 mL	3.6055 mL
20mM	0.0901 mL	0.4507 mL	0.9014 mL	1.8027 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.