Desfluoro-ezetimibe
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1685 | To Be Confirmed |
| 200mg | $2525 | To Be Confirmed |
| 500mg | $4260 | To Be Confirmed |
: Cat #: V39578 CAS #: 302781-98-2 Purity ≥ 99%
Description: Desfluoro-ezetimibe is the defluorinated impurity of ezetimibe (SCH-58235; SCH 58235; Zetia, Ezetrol), which is a Niemann-Pick C1-like1 (NPC1L1) inhibitor and an effective Nrf2 activator, and has been used to lower cholesterol levels.
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| Molecular Weight (MW) | 391.43 |
|---|---|
| Molecular Formula | C24H22FNO3 |
| CAS No. | 302781-98-2 |
| Synonyms | Desfluoroezetimibe; Desfluoro ezetimibe |
| Protocol | In Vitro | During the synthetic process development studies of Ezetimibe, an impurity was detected in the final product at levels ranging from 0.05% to 0.15% in reverse phase gradient high performance liquid chromatography (HPLC) method and its molecular weight is determined by LC–MS analysis. The impurity is Desfluoro-ezetimibe. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5547 mL | 12.7737 mL | 25.5474 mL | 51.0947 mL |
| 5mM | 0.5109 mL | 2.5547 mL | 5.1095 mL | 10.2189 mL |
| 10mM | 0.2555 mL | 1.2774 mL | 2.5547 mL | 5.1095 mL |
| 20mM | 0.1277 mL | 0.6387 mL | 1.2774 mL | 2.5547 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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Volume(start)
V1
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Concentration(final)
C2
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V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.