Ezetimibe ketone

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$2655	To Be Confirmed
200mg	$3980	To Be Confirmed
500mg	$6715	To Be Confirmed

: [email protected] [email protected]

Cat #: V40227 CAS #: 191330-56-0 Purity ≥ 99%

Description: Ezetimibe ketone is a phase-I metabolite of Ezetimibe (SCH58235; SCH-58235; Zetia, Ezetrol), which is a selective inhibitor of cholesterol absorption in the gut used to lower cholesterol levels.

References: Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. Synthetic Communications. 2016, 46:20, 1687-1693.

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Molecular Weight (MW)	407.41
Molecular Formula	C24H19F2NO3
CAS No.	191330-56-0
SMILES Code	O=C1N([C@@H]([C@H]1CCC(C2=CC=C(C=C2)F)=O)C3=CC=C(C=C3)O)C4=CC=C(C=C4)F
Synonyms	Ezetimibe ketone; EZM-K; EZM K

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4545 mL	12.2726 mL	24.5453 mL	49.0906 mL
5mM	0.4909 mL	2.4545 mL	4.9091 mL	9.8181 mL
10mM	0.2455 mL	1.2273 mL	2.4545 mL	4.9091 mL
20mM	0.1227 mL	0.6136 mL	1.2273 mL	2.4545 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.