NF-κB-IN-1 | CAS 1227098-15-8

NF-κB-IN-1

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250mg	$4800	Check With Us
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Cat #: V2438 CAS #: 1227098-15-8 Purity ≥ 99%

Description: NF-κB-IN-1 is a novel and potent NF-κB signaling pathway inhibitor can directly inhibit IKK and block NF- κ B activation.

References: Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53(23):8260-73.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	530.57
Molecular Formula	C31H30O8
CAS No.	1227098-15-8
SMILES Code	O=C(/C(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)=C/C2=CC=C(O)C(OC)=C2)/C=C/C3=CC=C(OC)C(OC)=C3
Synonyms	NF-κB-IN-1; NF-\|EB-IN-1; CHEMBL1800965; NF-kappaB-IN-1

Protocol	In Vitro	NF-κB-IN-1 (0.1-0.4 μM; 9 d) inhibits lung cancer clonogenic activity. NF-κB-IN-1 (0.1-100 μM; pretreated for 30 min) dose-dependently inhibits the TNFα-induced nuclear translocation of NF-κB in A549 cells, with an IC50s of 1.0 μM. NF-κB-IN-1 (0.5-25 μM; pretreated for 30 min or 4 h) potently blocks the IκB phosphorylation and degradation in A549 cells. NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI50s of 0.72, 0.07, 0.13, and 0.16 μM, respectively.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8848 mL	9.4238 mL	18.8477 mL	37.6953 mL
5mM	0.3770 mL	1.8848 mL	3.7695 mL	7.5391 mL
10mM	0.1885 mL	0.9424 mL	1.8848 mL	3.7695 mL
20mM	0.0942 mL	0.4712 mL	0.9424 mL	1.8848 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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