Amlexanox (AA673; CHX3673)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$450	Check With Us
5g	$850	Check With Us
10g	$1275	Check With Us

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Cat #: V11455 CAS #: 68302-57-8 Purity ≥ 99%

Description: Amlexanox (Amoxanox; AA-673; CHX-3673) is a potent and selective IKKε and TBK1 inhibitor which acts as anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions.

References: Reilly SM, et al. An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar;19(3):313-21.

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Molecular Weight (MW)	298.29
Molecular Formula	C16H14N2O4
CAS No.	68302-57-8
SMILES Code	CC(C)C1=CC2=C(C=C1)OC3=NC(=C(C=C3C2=O)C(=O)O)N
Synonyms	CHX 3673; CHX-3673; CHX3673; AA-673; AA673; AA 673; Amoxanox, Brand name: Aphthasol

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.3524 mL	16.7622 mL	33.5244 mL	67.0488 mL
5mM	0.6705 mL	3.3524 mL	6.7049 mL	13.4098 mL
10mM	0.3352 mL	1.6762 mL	3.3524 mL	6.7049 mL
20mM	0.1676 mL	0.8381 mL	1.6762 mL	3.3524 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.