GSK319347A
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1250 | Check With Us |
| 250mg | $1950 | Check With Us |
| 500mg | $2925 | Check With Us |
: Cat #: V3566 CAS #: 862812-98-4 Purity ≥ 98%
Description: GSK319347A is a novel, potent and dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively.
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| Molecular Weight (MW) | 469.53 |
|---|---|
| Molecular Formula | C₂₂H₁₉N₃O₅S₂ |
| CAS No. | 862812-98-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | N#CC1=C(OCC2=CC=CC=C2S(=O)(C)=O)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1 |
| Synonyms | GSK-319347A; GSK-319347A; GSK-319347A; |
| Protocol | In Vitro | GSK319347A (Compound 1) inhibits TBK1 enzyme with an IC50 of 93 nM, which also translates into good cell potency (72 nM). Moreover, IKK-3 Inhibitor exhibits excellent selectivity against cell-cycle kinases CDK2 and AurB. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1298 mL | 10.6489 mL | 21.2979 mL | 42.5958 mL |
| 5mM | 0.4260 mL | 2.1298 mL | 4.2596 mL | 8.5192 mL |
| 10mM | 0.2130 mL | 1.0649 mL | 2.1298 mL | 4.2596 mL |
| 20mM | 0.1065 mL | 0.5324 mL | 1.0649 mL | 2.1298 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.