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OSI-420 (Desmethyl Erlotinib) HCl

This product is for research use only, not for human use. We do not sell to patients.

OSI-420 (Desmethyl Erlotinib) HCl
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500mg$1950Check With Us
1g$2925Check With Us
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Cat #: V0562 CAS #: 183320-51-6 Purity ≥ 98%

Description: OSI-420 HCl (also known as CP-473420; OSI420; Desmethyl Erlotinib), the demethylated and active metabolite of erlotinib, is a potent, selective, orally bioavailable and ATP competitive inhibitor of tyrosine kinase EGFR with potential antineoplastic activity.

References: Thappali SR, et al. Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation.Sci Pharm

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Molecular Weight (MW)415.87
Molecular FormulaC21H21N3O4.HCl
CAS No.183320-51-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 83 mg/mL (199.6 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SMILES CodeCOCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCO
SynonymsDesMethyl Erlotinib (CP-473420) HCl; CP-473420; OSI420; OSI-420; OSI 420; CP473420; CP 473420; OSI-420 HCl; OSI-420 Hydrochloride
ProtocolIn VitroDesmethyl Erlotinib exhibits t1/2 of 11.96±2.01 h in a pharmacokinetic study in Wistar rats.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4046 mL12.0230 mL24.0460 mL48.0920 mL
5mM0.4809 mL2.4046 mL4.8092 mL9.6184 mL
10mM0.2405 mL1.2023 mL2.4046 mL4.8092 mL
20mM0.1202 mL0.6011 mL1.2023 mL2.4046 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.