AG-18 (RG50858, TX-825)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $600 | Check With Us |
| 500mg | $1020 | Check With Us |
| 1g | $1530 | Check With Us |
: Cat #: V0549 CAS #: 118409-57-7 Purity ≥ 98%
Description: AG-18 (also known as RG-50810, RG-50858, TX 825, Tyrphostin A23 and Tyrphostin AG-18) is a novel and potent EGFR inhibitor with an IC50 and Ki of 35 and 11 μM, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 186.17 |
|---|---|
| Molecular Formula | C10H6N2O2 |
| CAS No. | 118409-57-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 37 mg/mL (198.7 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 37 mg/mL (198.7 mM) | |
| SMILES Code | N#C/C(C#N)=C/C1=CC=C(O)C(O)=C1 |
| Synonyms | TX-825; RG-50810, Tyrphostin A23, TX 825; AG-18; AG18; Tyrphostin A-23; RG50810; RG 50810;AG 18; RG-50858; TX825; Tyrphostin 23; Tyrphostin A23; Tyrphostin AG-18. |
| Protocol | In Vitro | 10 μM tyrphostin 23 causes significant inhibition of the cell proliferation caused by 1 nM and 1μM ghrelin. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.3714 mL | 26.8572 mL | 53.7143 mL | 107.4287 mL |
| 5mM | 1.0743 mL | 5.3714 mL | 10.7429 mL | 21.4857 mL |
| 10mM | 0.5371 mL | 2.6857 mL | 5.3714 mL | 10.7429 mL |
| 20mM | 0.2686 mL | 1.3429 mL | 2.6857 mL | 5.3714 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
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Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.