Osimertinib (AZD9291; Tagrisso)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $250 | Check With Us |
| 5g | $500 | Check With Us |
| 10g | $750 | Check With Us |
: Cat #: V0546 CAS #: 1421373-65-0 Purity ≥ 98%
Description: Osimertinib (formerly AZD-9291 and mereletinib; trade name Tagrisso) is an oral bioavailable, irreversible/covalent, and mutant-selective EGFR inhibitor with potential antineoplastic activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 499.61 |
|---|---|
| Molecular Formula | C28H33N7O2 |
| CAS No. | 1421373-65-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 99 mg/mL (198.12 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 43 mg/mL (86.01 mM) | |
| Solubility In Vivo | 1% DMSO+30% PEG 300+dd H2O: 30mg/mL |
| SMILES Code | C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O |
| Synonyms | AZD-9291; AZD9291; AZD 9291; Osimertinib free base; Mereletinib; Trade name: Tagrisso |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0016 mL | 10.0078 mL | 20.0156 mL | 40.0312 mL |
| 5mM | 0.4003 mL | 2.0016 mL | 4.0031 mL | 8.0062 mL |
| 10mM | 0.2002 mL | 1.0008 mL | 2.0016 mL | 4.0031 mL |
| 20mM | 0.1001 mL | 0.5004 mL | 1.0008 mL | 2.0016 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.