Gefitinib (ZD 1839)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $150 | Check With Us |
| 10g | $250 | Check With Us |
| 20g | $375 | Check With Us |
: Cat #: V0534 CAS #: 184475-35-2 Purity ≥ 98%
Description: Gefitinib (formerly ZD1839, ZD-1839 or trade name: Iressa) is a potent and orally bioavailable EGFR inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 446.90 |
|---|---|
| Molecular Formula | C22H24ClFN4O3 |
| CAS No. | 184475-35-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 89 mg/mL (199.1 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 4 mg/mL (9.0 mM) | |
| Solubility In Vivo | 5% DMSO+corn oil: 2.5 mg/mL |
| SMILES Code | COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4CCOCC4 |
| Synonyms | ZD-1839; ZD1839; ZD 1839; Gefitinib; Brand name: Iressa. |
| Protocol | In Vitro | Gefitinib (0.01-0.1 μM, 72 h) results in increased phosphotyrosine load of the receptor, increased signalling to ERK and stimulation of proliferation and anchorage-independent growth. |
|---|---|---|
| In Vivo | Gefitinib (Oral administration, 75 mg/kg/d, 21 days) inhibits the M2-like polarization of macrophages in LLC mice metastasis model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2376 mL | 11.1882 mL | 22.3764 mL | 44.7527 mL |
| 5mM | 0.4475 mL | 2.2376 mL | 4.4753 mL | 8.9505 mL |
| 10mM | 0.2238 mL | 1.1188 mL | 2.2376 mL | 4.4753 mL |
| 20mM | 0.1119 mL | 0.5594 mL | 1.1188 mL | 2.2376 mL |
| Quality Control Documentation |
|
|---|
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.