JBJ-04-125-02 HCL
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1320 | Check With Us |
| 250mg | $1980 | Check With Us |
| 500mg | $2970 | Check With Us |
: Cat #: V40813 CAS #: 2140807-05-0 Purity ≥ 99%
Description: JBJ-04-125-02 HCL is a novel, highly potent, mutant-specific, allosteric and orally bioavailable EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M.
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| Molecular Weight (MW) | 543.61 |
|---|---|
| Molecular Formula | C29H26FN5O3S |
| CAS No. | 2140807-05-0 |
| SMILES Code | O=C(C(N1C(C(C=C(C2=CC=C(N3CCNCC3)C=C2)C=C4)=C4C1)=O)C5=C(O)C=CC(F)=C5)NC6=NC=CS6 |
| Synonyms | JBJ-04-125-02, JBJ04-125-02; JBJ 04-125-02; JBJ-0412502, JBJ0412502; JBJ 0412502; JBJ-04-125-02 racemate; |
| Protocol | In Vitro | JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8396 mL | 9.1978 mL | 18.3955 mL | 36.7911 mL |
| 5mM | 0.3679 mL | 1.8396 mL | 3.6791 mL | 7.3582 mL |
| 10mM | 0.1840 mL | 0.9198 mL | 1.8396 mL | 3.6791 mL |
| 20mM | 0.0920 mL | 0.4599 mL | 0.9198 mL | 1.8396 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.