AMG-Tie2-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2400 | Check With Us |
| 200mg | $3600 | Check With Us |
| 500mg | $6075 | Check With Us |
: Cat #: V2156 CAS #: 870223-96-4 Purity ≥ 98%
Description: AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 479.45 |
|---|---|
| Molecular Formula | C25H20F3N5O2 |
| CAS No. | 870223-96-4 |
| SMILES Code | FC(F)(F)C1=CC=CC(NC(C2=CC=C(C)C(OC3=NC=CC=C3C4=NC(NC)=NC=C4)=C2)=O)=C1 |
| Synonyms | AMG-Tie2-1 |
| Protocol | In Vitro | AMG-Tie2-1 (compound 15) inhibits Tie-2 phosphorylation in EA.hy926 human endothelial cells (IC50=10 nM). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0857 mL | 10.4286 mL | 20.8572 mL | 41.7145 mL |
| 5mM | 0.4171 mL | 2.0857 mL | 4.1714 mL | 8.3429 mL |
| 10mM | 0.2086 mL | 1.0429 mL | 2.0857 mL | 4.1714 mL |
| 20mM | 0.1043 mL | 0.5214 mL | 1.0429 mL | 2.0857 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
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Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.