Lenvatinib mesylate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$250	Check With Us
1g	$450	Check With Us
5g	$1140	Check With Us

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Cat #: V3700 CAS #: 857890-39-2 Purity ≥ 98%

Description: Lenvatinib mesylate (also known as E-7080, E7080, ER-203492-00; Lenvima), the mesylate salt of lenvatinib, is a multi-targeted and orally bioavailable inhibitor of VEGFR2(KDR)/VEGFR3(Flt-4) approved in 2015 for the treatment of differentiated thyroid cancer.

References: Kudo M, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellularcarcinoma: a randomised phase 3 non-inferiority trial. Lancet. 2018 Mar 24;391(10126):1163-1173.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	522.96
Molecular Formula	C22H23ClN4O7S
CAS No.	857890-39-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >100 mg/mLr
	Water: NAr
	Ethanol: NA
Solubility In Vivo	0.5% methylcellulose: 30 mg/kg
SMILES Code	O=C(C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(NC4CC4)=O)C(Cl)=C3)C2=C1)N.OS(=O)(C)=O
Synonyms	E-7080 mesylate; E7080; E 7080; ER-203492-00 mesylate; Lenvatinib mesylate; Brand name Lenvima

Protocol	In Vitro	Lenvatinib mesylate (E7080 mesylate) has IC50s of 4, 5.2, 22 nM for VEGFR2(KDR), VEGFR3(Flt-4), and VEGFR1/Flt-1, respectively. Lenvatinib inhibits PDGFRα, PDGFRβ, FGFR1, and KIT with IC50s of 51, 39, 46, 100 nM, respectively.
Protocol	In Vivo	Lenvatinib mesylate (E7080 mesylate) (100 mg/kg, p.o.) is administeredand bevacizumab significantly inhibits local tumor growth at the m.f.p., and at the end of treatment, Lenvatinib mesylate also significantly inhibits metastasis to both regional lymph nodes and distant lung.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9122 mL	9.5610 mL	19.1219 mL	38.2438 mL
5mM	0.3824 mL	1.9122 mL	3.8244 mL	7.6488 mL
10mM	0.1912 mL	0.9561 mL	1.9122 mL	3.8244 mL
20mM	0.0956 mL	0.4780 mL	0.9561 mL	1.9122 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.