Dovitinib Dilactic Acid (TKI258; CHIR258)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$1050	Check With Us
1g	$1650	Check With Us
5g	$4175	Check With Us

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Cat #: V0516 CAS #: 852433-84-2 Purity ≥ 98%

Description: Dovitinib (formerly also known as TKI-258 or CHIR-258) is a potent, orally bioavailable and multi-targeted RTK (receptor tyrosine kinase) inhibitor with potential antineoplastic activity.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	572.59
Molecular Formula	C21H21FN6O.2C3H6O3
CAS No.	852433-84-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 90 mg/mL (157.2 mM)r
	Water: 70 mg/mL (122.3 mM)r
	Ethanol:<1 mg/mL
Solubility In Vivo	Saline: 30 mg/kg
SMILES Code	CC(O)C(O)=O.O=C1NC2=C(C(F)=CC=C2)C(N)=C1C3=NC4=CC=C(N5CCN(C)CC5)C=C4N3
Synonyms	TKI-258, CHIR-258; TKI258; TKI 258; CHIR258; CHIR 258; TKI258 Dilactic acid

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7465 mL	8.7323 mL	17.4645 mL	34.9290 mL
5mM	0.3493 mL	1.7465 mL	3.4929 mL	6.9858 mL
10mM	0.1746 mL	0.8732 mL	1.7465 mL	3.4929 mL
20mM	0.0873 mL	0.4366 mL	0.8732 mL	1.7465 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.